|Vermillion is located in the Southeast corner of South Dakota near the intersection of Interstate 29 and South Dakota Highway 50. Home to the University of South Dakota. Vermillion also boasts an excellent school system, two clinics, and the medical center including family medicine clinic, hospital, nursing home and senior living apartments.. Various recreation activities abound, including bike paths, four city parks, an 18-hole golf course and much more. There are also many arts and entertainment events, plus festivals that our city hosts throughout the year.